Scandinavian Starch for Severe Sepsis/Septic Shock (6S) Trial reported at ISICEM 2012, Brussels

Conflicting clinical trial data: a lesson from albumin.
Conflicting clinical trial data: a lesson from albumin.

Martin G
Crit care 2005;9(6):649-50. Epub 2005 Nov 22

Assistant Professor of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, Georgia, USA. This e-mail address is being protected from spambots. You need JavaScript enabled to view it .

ABSTRACT : Albumin is a frequently prescribed drug in hospitalized patients, and its effect on clinical outcomes has been scrutinized in recent years.
Data from meta-analyses has suggested harm related to albumin therapy in critically ill patients, and new observational data are consistent with these results. However, appropriately powered randomized, controlled trials have shown albumin to be safe in broad groups of critically ill patients. This article will discuss the reasons for differences between observational and controlled trial data, and the implications for future albumin use and clinical research.
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