Influence of long-term administration of serum albumin on the prognosis of liver cirrhosis in man.
Influence of long-term
administration of serum albumin on the prognosis of liver cirrhosis in man.
Tarao K, Iwamura
Tokai J Exp Clin Med 1983
To investigate the efficacy of long
term administration of salt-poor albumin in the prognosis of cirrhotic patients
with ascites, we administered albumin for more than six months at regular
intervals to nine cirrhotic patients who had been confirmed to have ascites for
the first time, and maintained their serum albumin levels above 3.0 g/dl. The
other 11 cirrhotic patients who had also developed ascites for the first time
were treated with diuretics only, as a control group. In the albumin treated
group, one patient developed a hepatoma, and another had acute viral hepatitis
after transfusion during splenectomy, and they were excluded. In the control
group, one developed chronic liver failure after an operation for
choledocholithiasis, and she was excluded from the study. All seven patients who
had been administered albumin survived for more than two years, whereas three
out of 10 in the control group died of chronic liver failure within two years.
In the patients who showed a B.S.P. retention rate of more than 35% at the
beginning of the study, all five treated with albumin survived for more than two
years, whereas three out of four in the control group died within two years (P
less than 0.025). In the albumin treated patients, the increase in serum albumin
level was generally accompanied by an increase in the choline-esterase level.
Long term administration of serum albumin to cirrhotic patients with ascites
appears to lead to a better prognosis.